Spot cleaning with new ham

[Ang2020]

Hi

I've had my Syrian for three nights now. She is very nervous and has mostly hidden behind her wheel. She comes out around 8pm for a drink and then we don't see her until midnight which by that time I'm already in bed. Being from a breeder who has regularly handled her, I thought she would be less wary. But I have been leaving her alone to get used to us. When I see her I talk to her but she freezes and then darts back to her bed.

My question, how do I spot clean with a nervous ham? I'm not sure where here toilet area is yet but I dont want to scare her by taking the wire cage off and messing up her stuff. I already has to replace some substrate as the water bottle leaked and she hissed at me! Any advice welcome.