Hi there! I have used a detolf for all my hamsters so far and as others have said, there isn't a simple answer. I found that with paper bedding I needed to clean more often (once a month). These days I use aubiose and I mostly do spot cleaning. Cocoa tends to pee in the same corner so I can clean that corner more often while leaving the rest of the substrate alone a lot of the time! With her specifically, I don't really need to do very deep cleans. With my first hamster, I would do a deeper clean more often. Younger hamsters also tend to be a bit messier in my experience!
Spot clean and when things are seeming to get too messy, you can do a bigger clean! that's my experience anyways