I have a similar problem.
My winter white hamster "Brownie" is quite fine relaxing in his cage and sleeping. He also has a wheel he loves, a huge cage (probably fit for 3 or 4 dwarf hamsters) and a lot of tubes.
The only thing that sometimes annoys my is that he seems unable to calm down when I handle him. He at first always climbs onto my hand when I put it in the cage and stays put until I lift him out. Once I have him out he will become more and more hyper by the second.
He won't sit still or eat food (if he sees food he will actually ignore it or quickly stuff it in his cheeks). He seems to need to explore everything he can and as soon as he's done with that he won't stop trying to escape to then explore further. It also doesn't depend on how long I have him out of his cage. He just gets more and more active.
Is there any way that I could use to calm him down that I haven't already tired? I've tried:
- extra exercise,
- feeding him outside the cage (since he mainly looks so peaceful when eating in his cage),
- gently holding him until he calms down (he won't calm down and just struggle up to the point where I feel that I need to let go since I'd otherwise hurt him) and
- petting him (seems pretty useless... especially since he won't sit still)
P.S.:
I am pretty sure that he isn't scared of me. He has bitten very rarely (twice in 7 months) when I put my hand in the cage and he was in a bad mood, but he never bites me when I have him out of the cage. He also never spits his food at me and he also never pees when he's out of the cage.