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I would do it when he's awake, if you can do it when he's out of it that might be better but that depends if you want to do it at 2am! He won't be happy about it for a while but he hasn't been in there longs so he should settle again soon enough, if you can it may be best to take him out & put him in a carrier with some of his substrate while you rearrange things that way he should get less stressed.