[Pebbles82]

The set up is very nice and looks fine - but sometimes people clean out a bit too often and if the nest and/or hoard is removed it will drive her frantic -also if it's a big clean out as that removes all their scent, after they've scent marked everything to "claim" it and find their way around.

Best thing is to just spot clean as and when necessary and not do a full cage clean - that way you can go 2 months or more without needing to change the substrate, especially if she uses a litter tray (which you just empty every 5 days or so). And even then it's best not to replace all the substrate and to put some of the old/clean back and mix it in so it still smells familiar. It's their territorial instinct, plus they like cosy and familiar!

The only other thing I can think is - they do need somewhere nice and dark to retreat to in the cage - so a large-ish house that is dark inside is important (didn't notice if you had that in your photo). Something like a shoebox with a hole cut for a door. If you cut the bottom out and use the lid as a lift off roof you can check inside without having to take the house out or the nest collapsing.

Whatever the cause, it could be an idea to add something like a shoebox house now - pop it over her nest (if it's an open nest - if not just put it somewhere and a bendy bridge tunnel over the door which should tempt her inside as it's a tunnel entrance and will be nice and dark - also put the odd treat inside.