Well,yes but I have never had a problem but right now one of my hamsters is on carefresh and the other one isn't because I have yet to switch him over to carefresh!!!
You could go for a cheaper option and get horse bedding such as megazorb,auboise or fitch which are much cheaper for the amount you get or EVEN cheaper you could shred some paper up in a shredding machine, plain white paper, and give your hamster that but it won't absorb as good so give him/her a nice big thick layer and do spot cleans!!!